Edouard André, hailing from a Protestant banking family, utilized his vast wealth to acquire pieces of art, which he then showcased in his newly built mansion in 1869 by architect Henri Parent. The mansion's construction was completed in 1875.
Ten years prior to this, Edouard André had his portrait painted by a renowned society painter, Nélie Jacquemart, whom he later married. The couple frequently traveled to Italy, where they amassed an exceptional collection of Italian art in France. After Edouard André's demise, Nélie Jacquemart finished adorning the Italian Museum and continued traveling to the Orient to obtain additional valuable works for the collection. In accordance with her husband's wishes, she left the mansion and its collections to the Institut de France as a museum, which was eventually opened to the public in 1913.
There are five main parts to the museum which are:
The museum features works by Élisabeth-Louise Vigée Le Brun, Bellini, Francesco Botticini, Luca Signorelli, Cima da Conegliano, Pietro Perugino, Neri di Bicci, Vittore Crivelli, Luca della Robbia, Paolo Uccello, Canaletto, Jean-Marc Nattier, Alfred Boucher, Quentin Massys, Rembrandt, Anthony van Dyck, Frans Hals, Giovanni Battista Tiepolo, Jacques-Louis David, Franz Xaver Winterhalter, Thomas Lawrence, Joshua Reynolds, Thomas Gainsborough, Gian Lorenzo Bernini, Sandro Botticelli, Andrea Mantegna, Jean-Honoré Fragonard, and Jean-Baptiste-Siméon Chardin.
During the filming of the 1958 film Gigi, both the forecourt and a salon were utilized. Meanwhile, a reproduction of the Grand Salon and the Honor Staircase from the Musée Jacquemart-André, but without the partition wall in-between, was used to shoot the concluding banquet scene of Kevin Reynolds' 2002 film The Count of Monte Cristo.